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These restrictions could ultimately lead to severe nutritional deficiencies, making such cleanses unbalanced and unsafe. Weight loss cleanses differ Bactenormin asli as they often eliminate vital nutritional components — such as protein — without providing any guidance for replacing them during the cleanse. Interestingly, one 15-week study showed that short-term, rapid weight loss by way of a VLCD was more effective at lowering cholesterol and blood sugar than slower, sustained methods for weight loss .